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Issue 30, 2018
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A functional preservation strategy for the production of highly photoluminescent emerald carbon dots for lysosome targeting and lysosomal pH imaging

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Abstract

Lysosomes, which can be easily targeted by molecules with abundant amino groups, play critical roles in endocytosis, autophagy, and phagocytosis; thus, it is important to accurately characterize lysosomes, including lysosomal pH, in living cells to understand their physiological and pathological functions. Herein, a new type of highly photoluminescent (PL) emerald carbon dots (CDs) was easily prepared through a functional preservation strategy (FPS) by simply mixing p-benzoquinone and ethanediamine at room temperature. The as-prepared CDs possessed abundant amino groups preserved from ethanediamine owing to FPS, and they exhibited excellent photostability as compared to the commercial LysoTracker probes. Consequently, they actively targeted lysosomes to sensitively respond to lysosomal pH in vitro owing to their abundant amino groups and good hydrophilicity. Thus, we could successfully monitor lysosomal pH dynamics during apoptosis in live cells.

Graphical abstract: A functional preservation strategy for the production of highly photoluminescent emerald carbon dots for lysosome targeting and lysosomal pH imaging

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Publication details

The article was received on 19 Apr 2018, accepted on 09 Jul 2018 and first published on 11 Jul 2018


Article type: Paper
DOI: 10.1039/C8NR03212B
Citation: Nanoscale, 2018,10, 14705-14711
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    A functional preservation strategy for the production of highly photoluminescent emerald carbon dots for lysosome targeting and lysosomal pH imaging

    Q. Q. Zhang, T. Yang, R. S. Li, H. Y. Zou, Y. F. Li, J. Guo, X. D. Liu and C. Z. Huang, Nanoscale, 2018, 10, 14705
    DOI: 10.1039/C8NR03212B

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