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Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors

Abstract

Photoacoustic imaging (PAI) is a new and attractive imaging modality, it has strong potential as a efficient way for early detection of tumor through the use of optically absorbing targeted contrast agents. Ag2S quantum dot (QD) is a promising bionanomaterial and has attracted significant attentions in the field of bioimaging. In this study, water-soluble and carboxylic acid group-coated Ag2S QDs with ultrasmall size (~8 nm) were synthesized via a one-step method. Their surface plasmon resonance wavelength was determined to be ~800 nm, which is ideal for PAI. Ag2S QDs were then modified with epidermal growth factor receptor 1 (EGFR) targeted small protein Affibody ZEGFR:1907. The resulted nanoprobe, ZEGFR:1907-Ag2S QDs were then used for targeted PAI of EGFR-overexpressed tumors. The biodistribution of the nanoprobe was further measured by ex vivo near infrared fluorescent (NIRF) imaging of dissected tissues. The PAI results showed that ZEGFR:1907-Ag2S QDs specifically image EGFR positive tumors. The biodistribution study revealed that the nanoprobe mainly accumulated in liver, spleen and tumor, tissue H&E staining studies indicated that the probe has good biocompatibility. Overall, the affibody-functionalized Ag2S QDs is a novel targeted nanoprobe that can be used for specific PAI of tumor.

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Publication details

The article was received on 29 Mar 2018, accepted on 29 Jul 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR02556H
Citation: Nanoscale, 2018, Accepted Manuscript
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    Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors

    Y. Zhang, Z. NING, Q. YESHAN, W. Fengxia, X. ZHIHUA, L. TIAN, Z. Cheng, Z. PING and H. Liu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02556H

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