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Issue 25, 2018

Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines

Author affiliations

Abstract

Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell, but are often oxidized in order to modify their surface chemistry for targeting to specific cellular compartments. Here, we assessed the biological impact of this purification process, considering cellular proliferation, uptake, and oxidative stress for graphitic and oxidized nanodiamond surfaces. We show for the first time that oxidized nanodiamonds possess improved biocompatibility compared to graphitic nanodiamonds in breast cancer cell lines, with graphitic nanodiamonds inducing higher levels of oxidative stress despite lower uptake.

Graphical abstract: Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines

Supplementary files

Article information


Submitted
15 Mar 2018
Accepted
18 May 2018
First published
19 Jun 2018

This article is Open Access

Nanoscale, 2018,10, 12169-12179
Article type
Paper

Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines

B. Woodhams, L. Ansel-Bollepalli, J. Surmacki, H. Knowles, L. Maggini, M. de Volder, M. Atatüre and S. Bohndiek, Nanoscale, 2018, 10, 12169 DOI: 10.1039/C8NR02177E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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