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A Novel Fluorescent Adhesive-assisted Biomimetic Mineralization

Abstract

We propose a novel fluorescent adhesive-assisted biomimetic mineralization strategy, based on which 1 wt % of sodium fluorescein and 25 wt % of polyacrylic acid stabilized amorphous calcium phosphate (PAA-ACP) nanoparticles were incorporated into a mild self-etch adhesive (Clearfil S3 Bond) as a fluorescent mineralizing adhesive. The characterizations of the PAA-ACP nanoparticles indicate that they were spheric particles clustered together, each particle in a diameter of approximately 20~50 nm, in a metastable phase with two characteristic absorption peaks (1050 cm−1 and 580 cm−1). Our results suggest that the fluorescent mineralizing adhesive was non-cytotoxic with minimal esthetic interference and its fluorescence intensity did not significantly decrease within 6 months. Our data reveal that the fluorescent mineralizing adhesive could induce the extra- and intra-fibrillar remineralization of the reconstituted type I collagen, the demineralized enamel and dentin substrate. Our data demonstrate that a novel fluorescent adhesive-assisted biomimetic mineralization strategy will pave the way to design and produce anti-carious materials for the prevention of dental caries.

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Publication details

The article was received on 13 Mar 2018, accepted on 05 Aug 2018 and first published on 10 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR02078G
Citation: Nanoscale, 2018, Accepted Manuscript
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    A Novel Fluorescent Adhesive-assisted Biomimetic Mineralization

    Z. Wang, Y. Ouyang, Z. Wu, L. Zhang, C. Shao, J. Fan, L. Zhang, Y. Shi, Z. Zhou, H. Pan, R. Tang and B. Fu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02078G

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