Multi-affinity sites of magnetic guanidyl-functionalized metal–organic framework nanospheres for efficient enrichment of global phosphopeptides

Abstract

Magnetic guanidyl-functionalized metal–organic framework (MOF) nanospheres with multi-affinity sites composed of an inherent Zn–O cluster based on MOAC and specific recognized groups (amino group and guanidyl group) were for the first time synthesized by a combination strategy of epitaxial growth and post-synthetic modification of magnetic amino-derived MOFs, and they exhibit great potential for efficient enrichment of global phosphopeptides.