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Issue 14, 2018
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Tuning antimicrobial properties of biomimetic nanopatterned surfaces

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Abstract

Nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (<2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip geometry. Additionally, real-time imaging reveals how cells are immobilized and killed rapidly. Generic or selective protection from microbial colonization could be conferred to surfaces [for, e.g., internal medicine, implants (joint, dental, and cosmetic), food preparation, and the agricultural industry] patterned with these materials as coatings.

Graphical abstract: Tuning antimicrobial properties of biomimetic nanopatterned surfaces

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Publication details

The article was received on 16 Jan 2018, accepted on 12 Mar 2018 and first published on 27 Mar 2018


Article type: Paper
DOI: 10.1039/C8NR00439K
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Nanoscale, 2018,10, 6639-6650

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    Tuning antimicrobial properties of biomimetic nanopatterned surfaces

    M. Michalska, F. Gambacorta, R. Divan, I. S. Aranson, A. Sokolov, P. Noirot and P. D. Laible, Nanoscale, 2018, 10, 6639
    DOI: 10.1039/C8NR00439K

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