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Issue 13, 2018
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64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging

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We report the use of multifunctional folic acid (FA)-modified dendrimers as a platform to radiolabel with 64Cu for PET imaging of folate receptor (FR)-expressing tumors. In this study, amine-terminated generation 5 (G5) poly(amidoamine) dendrimers were sequentially modified with fluorescein isothiocyanate (FI), FA, and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), followed by acetylation of the remaining dendrimer terminal amines. The as-formed multifunctional DOTA-FA-FI-G5·NHAc dendrimers were then radiolabeled with 64Cu via the DOTA chelation. We show that the FA modification renders the dendrimers with targeting specificity to cancer cells overexpressing FR in vitro. Importantly, the radiolabeled 64Cu-DOTA-FA-FI-G5·NHAc dendrimers can be used as a nanoprobe for specific targeting of FR-overexpressing cancer cells in vitro and targeted microPET imaging of the FR-expressing xenografted tumor model in vivo. The developed 64Cu-labeled multifunctional dendrimeric nanoprobe may hold great promise to be used for targeted PET imaging of different types of FR-expressing cancer.

Graphical abstract: 64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging

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Publication details

The article was received on 13 Dec 2017, accepted on 18 Feb 2018 and first published on 20 Feb 2018

Article type: Paper
DOI: 10.1039/C7NR09269E
Citation: Nanoscale, 2018,10, 6113-6124

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    64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging

    W. Ma, F. Fu, J. Zhu, R. Huang, Y. Zhu, Z. Liu, J. Wang, P. S. Conti, X. Shi and K. Chen, Nanoscale, 2018, 10, 6113
    DOI: 10.1039/C7NR09269E

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