Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Engineered contrast agents in a single structure for T1T2 dual magnetic resonance imaging

Author affiliations


The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T1T2 dual-mode relaxivity requires the accurate assembly of T1 and T2 magnetic centers in a single structure. In this context, we have synthesized a novel hybrid material by monitoring the formation of Prussian Blue analogue Gd(H2O)4[Fe(CN)6] nanoparticles with tailored shape (from nanocrosses to nanorods) and size, and further protection with a thin and homogeneous silica coating through hydrolysis and polymerization of silicate at neutral pH. The resulting Gd(H2O)4[Fe(CN)6]@SiO2 magnetic nanoparticles are very stable in biological fluids. Interestingly, this combination of Gd and Fe magnetic centers closely packed in the crystalline network promotes a magnetic synergistic effect, which results in significant improvement of longitudinal relaxivity with regards to soluble Gd3+ chelates, whilst keeping the high transversal relaxivity inherent to the iron component. As a consequence, this material shows excellent activity as MRI CA, improving positive and negative contrasts in T1- and T2-weighted MR images, both in in vitro (e.g., phantom) and in vivo (e.g., Sprague-Dawley rats) models. In addition, this hybrid shows a high biosafety profile and has strong ability to incorporate organic molecules on the surface with variable functionality, displaying great potential for further clinical application.

Graphical abstract: Engineered contrast agents in a single structure for T1–T2 dual magnetic resonance imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Oct 2017, accepted on 25 Feb 2018 and first published on 26 Feb 2018

Article type: Paper
DOI: 10.1039/C7NR07948F
Citation: Nanoscale, 2018,10, 6349-6360

  •   Request permissions

    Engineered contrast agents in a single structure for T1T2 dual magnetic resonance imaging

    A. Cabrera-García, E. Checa-Chavarria, J. Pacheco-Torres, Á. Bernabeu-Sanz, A. Vidal-Moya, E. Rivero-Buceta, G. Sastre, E. Fernández and P. Botella, Nanoscale, 2018, 10, 6349
    DOI: 10.1039/C7NR07948F

Search articles by author