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Issue 2, 2018

Upconverting nanocomposites with combined photothermal and photodynamic effects

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Abstract

Lanthanide-doped upconverting nanoparticles (UCNPs) have been studied for diverse biomedical applications due to their inherent ability to convert near-infrared (NIR) excitation light to higher energies (spanning the ultraviolet, visible, and NIR regions). To explore additional functionalities, rational combination with other optically active nanostructures may lead to the development of new multimodal nanoplatforms with theranostic (therapy and diagnostic) capabilities. Here, we develop a nanocomposite consisting of NaGdF4:Er3+, Yb3+ UCNPs, mesoporous silica (SiO2), gold nanorods (GNRs) and a photosensitizer, with integrated functionalities including luminescence imaging, photothermal generation, nanothermometry and photodynamic effects. Under 980 nm irradiation, GNRs and UCNPs are simultaneously excited due to the overlap between the surface plasmon resonance of the GNRs and the absorption of the UCNPs leading to plasmonic enhancement of the upconverted luminescence, while concomitantly creating a temperature gradient. The temperature increase can be determined from the intensity ratio of the upconverted green emission of the UCNPs. Finally, a photosensitizer, zinc phthalocyanine, was loaded into the mesoporous SiO2. Upon laser irradiation, the upconverted visible light subsequently activates the photosensitizer to release reactive oxygen species. The multifunctional GNR@SiO2@UCNPs nanocomposites showed strong luminescence signal when incubated in HeLa cervical cancer cells, making them ideal bioprobes for future theranostic applications.

Graphical abstract: Upconverting nanocomposites with combined photothermal and photodynamic effects

Supplementary files

Article information


Submitted
26 Jul 2017
Accepted
03 Dec 2017
First published
06 Dec 2017

This article is Open Access

Nanoscale, 2018,10, 791-799
Article type
Paper

Upconverting nanocomposites with combined photothermal and photodynamic effects

Y. Huang, A. Skripka, L. Labrador-Páez, F. Sanz-Rodríguez, P. Haro-González, D. Jaque, F. Rosei and F. Vetrone, Nanoscale, 2018, 10, 791 DOI: 10.1039/C7NR05499H

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