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The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

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Abstract

Covering: 2000 to 2018

Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the “pericyclases,” are the subject of this review.

Graphical abstract: The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

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Publication details

The article was received on 19 Aug 2018 and first published on 12 Oct 2018


Article type: Review Article
DOI: 10.1039/C8NP00075A
Citation: Nat. Prod. Rep., 2018, Advance Article
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    The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

    C. S. Jamieson, M. Ohashi, F. Liu, Y. Tang and K. N. Houk, Nat. Prod. Rep., 2018, Advance Article , DOI: 10.1039/C8NP00075A

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