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Issue 10, 2018
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Protein–protein interactions in trans-AT polyketide synthases

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Abstract

Covering: up to 2018

The construction of polyketide natural products by type I modular polyketide synthases (PKSs) requires the coordinated action of several protein subunits to ensure biosynthetic fidelity. This is particularly the case for trans-AT PKSs, which in contrast to most cis-AT PKSs, contain split modules and employ several trans-acting catalytic domains. This article summarises recent advances in understanding the protein–protein interactions underpinning subunit assembly and intra-subunit communication in such systems and highlights potential avenues and approaches for future research.

Graphical abstract: Protein–protein interactions in trans-AT polyketide synthases

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Article information


Submitted
26 Jul 2018
First published
03 Oct 2018

Nat. Prod. Rep., 2018,35, 1097-1109
Article type
Review Article

Protein–protein interactions in trans-AT polyketide synthases

S. Kosol, M. Jenner, J. R. Lewandowski and G. L. Challis, Nat. Prod. Rep., 2018, 35, 1097
DOI: 10.1039/C8NP00066B

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