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The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins

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Abstract

Covering: up to May 2018

The verticillene family of 6,12-membered ring-fused diterpenes are found in plants, liverworts, corals and insects. Carbocations derived from verticillene hydrocarbons are central intermediates in the biosynthesis of the taxane and the phomactin families of polycyclic natural products. This perspective delineates these unique biosynthetic interrelationships, which are reinforced by recent biomimetic synthesis investigations, alongside quantum chemical calculations and targeted engineering studies of the taxadiene synthase (TXS) cascade.

Graphical abstract: The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins

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Publication details

The article was received on 13 Apr 2018 and first published on 06 Jul 2018


Article type: Review Article
DOI: 10.1039/C8NP00034D
Citation: Nat. Prod. Rep., 2018, Advance Article
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    The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins

    M. J. Palframan and G. Pattenden, Nat. Prod. Rep., 2018, Advance Article , DOI: 10.1039/C8NP00034D

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