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Issue 1, 2019
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Natural product syntheses via carbonylative cyclizations

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Covering: 2000–2018

In this review, we highlight recent examples of natural product total syntheses employing transition metal-mediated/catalyzed carbonylative cyclization strategies to build key ring systems. It mainly covers carbonylative cyclizations for the construction of O-heterocycles, N-heterocycles and carbocycles including cyclic ketones and phenols. The reaction types include carbonylation of epoxide to β-lactones, carbonylative (macro)lactonization/lactamization, the Semmelhack reaction, tandem hydroformylation–cyclization, the Pauson–Khand reaction, carbonylative C–H activation cyclization, the Stille/Suzuki carbonylation, [n + m + 1] carbonylative cycloaddition, the Dötz annulation, and others.

Graphical abstract: Natural product syntheses via carbonylative cyclizations

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Publication details

The article was received on 09 Apr 2018 and first published on 20 Jun 2018

Article type: Review Article
DOI: 10.1039/C8NP00033F
Nat. Prod. Rep., 2019,36, 174-219

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    Natural product syntheses via carbonylative cyclizations

    K. Ma, B. S. Martin, X. Yin and M. Dai, Nat. Prod. Rep., 2019, 36, 174
    DOI: 10.1039/C8NP00033F

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