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A genomics perspective on natural product biosynthesis in plant pathogenic bacteria

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Abstract

Covering: up to February 2018

In recent years, genome sequencing revealed the full biosynthetic potential of bacteria causing plant diseases. Bioinformatics and advanced analytical techniques paved the way to clarify the structures of long-sought natural products with a role in virulence. Furthermore, several compounds without disease-associated function were discovered. The exploration of these molecules disclosed persistence strategies of plant pathogenic bacteria outside their hosts and provided access to new bioactive compounds with therapeutic potential. In this review, we will summarize some of the striking findings in the field, paying particular attention to unique natural product pathways and their unprecedented biosynthetic features as well as the biological activities of the retrieved compounds.

Graphical abstract: A genomics perspective on natural product biosynthesis in plant pathogenic bacteria

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Publication details

The article was received on 27 Mar 2018 and first published on 31 Jul 2018


Article type: Review Article
DOI: 10.1039/C8NP00025E
Citation: Nat. Prod. Rep., 2018, Advance Article
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    A genomics perspective on natural product biosynthesis in plant pathogenic bacteria

    F. Baldeweg, D. Hoffmeister and M. Nett, Nat. Prod. Rep., 2018, Advance Article , DOI: 10.1039/C8NP00025E

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