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Issue 11, 2018
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Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

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Abstract

Covering: up to early 2018

Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C–C bonds, and nonribosomal peptide synthetases (NRPSs) assemble amino acids into peptides through amide bonds. PKS–NRPS hybrid assembly lines build structurally complex polyketide–amino acid/peptide hybrid molecules that incorporate both acyl and aminoacyl building blocks into their products. Their combined functionalities expand the biological activities of these molecules by mixing their chemical properties. Protein–protein interactions are necessary within PKS–NRPS hybrid assembly lines to achieve accurate linkage between the PKS and NRPS systems. This review summarizes the current understanding of the roles and importance of the protein–protein interactions in various PKS–NRPS hybrid assembly lines.

Graphical abstract: Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

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Publication details

The article was received on 06 Mar 2018 and first published on 03 Aug 2018


Article type: Review Article
DOI: 10.1039/C8NP00022K
Citation: Nat. Prod. Rep., 2018,35, 1185-1209
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    Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

    A. Miyanaga, F. Kudo and T. Eguchi, Nat. Prod. Rep., 2018, 35, 1185
    DOI: 10.1039/C8NP00022K

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