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Extending the Family of Quinolone Antibacterials to New Copper Derivatives: Self-assembly, Structural and Topological Features, Catalytic and Biological Activity

Abstract

New series of copper(II) compounds, [Cu(pef)2(MeOH)] (1), [Cu(pef)(bipyam)Cl] (2), [Cu(pef)(phen)Cl] (3) and [Cu(pef)(bipy)Cl] (4), bearing the quinolone family member pefloxacin (Hpef) was self-assembled in the presence (optional) of the N,N'-donor heterocyclic ligands such as 2,2'-bipyridylamine (bipyam), 1,10-phenanthroline (phen), or 2,2'-bipyridine (bipy). The products were fully characterized, including the single-crystal X-ray diffraction analysis of 2−4. The structures are extended into 1D (2), 2D (3), or 3D (4) networks via multiple H-bonds between the monocopper(II) units and guest water and/or methanol molecules; the latter are arranged into different types of water and hybrid water-methanol clusters. The resulting H-bonded networks were classified from the topological viewpoint, revealing diverse topologies that also include an undocumented type. Compounds 2−4 also act as homogeneous catalysts in a model oxidation reaction, namely the mild oxidation of C6−C8 cycloalkanes by H2O2 at 50 °C to give cyclic alcohols and ketones. Besides, products 1−4 also disclose a remarkable antibacterial activity against four different microorganisms (Escherichia coli, Xanthomonas campestris, Staphylococcus aureus and Bacillus subtilis), which can be superior to that of free Hpef. The interaction of the Cu(II) compounds with calf-thymus DNA was studied suggesting the intercalation as the most possible binding mode. Furthermore, the interaction of the obtained copper(II) derivatives with human/bovine serum albumin was investigated by fluorescence emission spectroscopy and the corresponding albumin-binding constants were established. This study widens a limited family of transition metal pefloxacin derivatives.

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Publication details

The article was accepted on 02 Nov 2018 and first published on 02 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ05338C
Citation: New J. Chem., 2018, Accepted Manuscript
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    Extending the Family of Quinolone Antibacterials to New Copper Derivatives: Self-assembly, Structural and Topological Features, Catalytic and Biological Activity

    P. Xerras, A. Bacharidou, S. Kalogiannis, F. Perdih, M. Kirillova, A. M. Kirillov, I. Turel and G. L. Psomas, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ05338C

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