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Platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles with allylic acetates in water

Abstract

Due to biological activity, indoles and substituted indoles have attracted considerable attention from both synthetic and medicinal scientists. Much effort has been directed toward the development of methods for functionalization of the indole nucleus. The protocol uses a catalytic amount of platinum-catalyzed as a promoting agent, providing N-allylated indoles in wonderful yields. Moreover, water with large heat capacity is one of the most abundant molecules on earth. Water is used as a solvent may bring about many environmental benefits. Herein, we have demonstrated that platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles react in water. This method provides a simple, convenient, and efficient way, which afforded high yield of N-allylated indoles.

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Publication details

The article was received on 05 Oct 2018, accepted on 05 Nov 2018 and first published on 09 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ05051A
Citation: New J. Chem., 2018, Accepted Manuscript
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    Platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles with allylic acetates in water

    B. Peng, W. Hsueh, F. Fulop and S. Yang, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ05051A

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