Photo-induced synthesis of chiral galaxamide analogs and the biological activities against human tumor cells

Abstract

Two novel chiral cyclic peptide analogues of galaxamide were synthesized by photoinduced single electron transfer cyclization. Their stereochemistry was studied by experimental and theoretical ECD simulations. The title compounds were found to be active against HepG-2 cell lines (IC₅₀ = 19.52 for 1 and 26.34 μg mL⁻¹ for 2).