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L-cysteine-Mediated, Iodide-Catalyzed Reaction for detection of I-

Abstract

In this paper, a highly selective and eco-friendly fluorescence sensor consisting of upconversion (UCNPs) and gold nanoparticles (AuNPs) has been developed for the detection of I-. The negatively charged AuNPs could be electrostatically adsorbed on the positively charged UCNPs, leading to the fluorescence quenching of UCNPs. In the presence of L-cysteine, AuNPs released from the surface of UCNPs and aggregated due to the Au-S interaction between AuNPs and L-cysteine, which resulted in the fluorescence recovery of UCNPs. Upon addition of I-, the fluorescence of UCNPs was quenched gradually in that I- can catalyze the oxidation of L-cysteine, preventing the aggregation of AuNPs and forming the fluorescence energy resonance transfer system. The I--catalyzed oxidation reaction provides a method of a L-cysteine-triggered sensor to detect I-, using L-cysteine to modulate the fluorescence signal, which manifests eco-friendly. Based on the above special detection strategies, this sensor has excellent selectivity for I- even in a complex matrix such as urine, which is much better than most assays for I-. Under the optimal conditions, the sensor allows the quantitative analysis of I- with a detection limit of 55 nM. The high selectivity, sensitivity and environmental friendliness of the sensor proves that it has the potential for the detection of I- in actual samples. Most importantly, the excellent results of the sensor for detection of I- in urine prove that the probe can be used as an ideal tool in clinic diagnoses.

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Publication details

The article was received on 29 Sep 2018, accepted on 25 Nov 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8NJ04944K
Citation: New J. Chem., 2018, Accepted Manuscript
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    L-cysteine-Mediated, Iodide-Catalyzed Reaction for detection of I-

    K. He, H. Chen, C. Wu, M. Liu and Y. Zhang, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04944K

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