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Issue 24, 2018
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An efficient synthesis of versatile synthon 3-chlorooxindoles with NaCl/oxone

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Abstract

The present work describes an expedient approach for the direct conversion of indole-3-carboxaldehyde to 3-chlorooxindoles using a simple sustainable synthetic method. From an environmental perspective, a combination of NaCl/oxone in a CH3CN : H2O (1 : 1) system was developed for direct oxidative chlorination of a wide array of indole derivatives. This chlorination strategy is more viable, remarkably cheaper and provides easy access to potential 3-chlorooxindoles. In addition, this environmentally benign method can also be applicable for constructing isatin derivatives in good yields.

Graphical abstract: An efficient synthesis of versatile synthon 3-chlorooxindoles with NaCl/oxone

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Supplementary files

Article information


Submitted
25 Sep 2018
Accepted
07 Nov 2018
First published
08 Nov 2018

New J. Chem., 2018,42, 20152-20155
Article type
Paper

An efficient synthesis of versatile synthon 3-chlorooxindoles with NaCl/oxone

V. Lakshmi Reddy, P. S. Prathima, V. J. Rao and R. Bikshapathi, New J. Chem., 2018, 42, 20152
DOI: 10.1039/C8NJ04855J

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