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Size and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

Abstract

Excess production of reactive oxygen species (ROS) such as hydroxyl (HO●) and superoxide (O2●-) radicals affects the metabolic process and plays a major role in diseases like cancer. Defects structured nano ceria is a potential material for mimicking various natural antioxidant enzymes. However, tuning the oxygen vacancy defects through a simple synthetic strategy still remains a challenge. Due to multi-enzymatic nature, ceria exhibit both pro-oxidant and anti-oxidant properties simultaneously which is vaguely understood and seriously limits its scope in therapeutics. Herein, we report the preparation of ceria nanoparticles using combustion method at various fuel (lean, stoichiometric and excess) condition and its influence on size and oxygen defects concentration are correlated to the structural, toxicity and antioxidant properties. The lower size and higher oxygen vacancy (Ce3+ sites) defects achieved at fuel lean condition significantly improved the antioxidant and radical scavenging properties as evidenced from enzyme kinetics. At low concentration ceria exhibit protective effects (eliminates HO● radicals and H2O2) but at higher concentration, it exhibits oxidase activity by generating O2●- radicals irrespective of pH conditions. Our results clearly demonstrate the activation of selective enzyme mimetic properties by controlling the ceria concentration which is of utmost important in antioxidant therapeutic and diagnostic applications.

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Publication details

The article was received on 31 Aug 2018, accepted on 11 Oct 2018 and first published on 11 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ04435J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Size and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

    V. G, A. Pandiyan, A. Mahesh, A. Dhayalan and S. Babu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04435J

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