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Poly(HPMA)-DTPA/DOTA-Gd conjugates for magnetic resonance imaging

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Abstract

Both poly(HPMA)-DTPA/DOTA-Gd conjugates were constructed in a facile manner and presented no significant side effects, as confirmed by cytotoxicity and hemocompatibility studies. The T1 relaxivity values of poly(HPMA)-DTPA/DOTA-Gd conjugates were about 7.8 and 8.6 mM−1 s−1. The r2/r1 ratio values were about 2.78 and 2.92; thus, both polymer conjugates are desirable candidates as magnetic resonance imaging contrast agents.

Graphical abstract: Poly(HPMA)-DTPA/DOTA-Gd conjugates for magnetic resonance imaging

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Publication details

The article was received on 27 Aug 2018, accepted on 27 Oct 2018 and first published on 02 Nov 2018


Article type: Letter
DOI: 10.1039/C8NJ04355H
Citation: New J. Chem., 2018, Advance Article
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    Poly(HPMA)-DTPA/DOTA-Gd conjugates for magnetic resonance imaging

    W. Xu, H. Long, X. Xu, G. Fu, L. Pu and L. Ding, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ04355H

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