Poly(HPMA)-DTPA/DOTA-Gd conjugates for magnetic resonance imaging

Abstract

Both poly(HPMA)-DTPA/DOTA-Gd conjugates were constructed in a facile manner and presented no significant side effects, as confirmed by cytotoxicity and hemocompatibility studies. The T₁ relaxivity values of poly(HPMA)-DTPA/DOTA-Gd conjugates were about 7.8 and 8.6 mM⁻¹ s⁻¹. The r₂/r₁ ratio values were about 2.78 and 2.92; thus, both polymer conjugates are desirable candidates as magnetic resonance imaging contrast agents.