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Issue 23, 2018
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Highly efficient nitrobenzene and alkyl/aryl azide reduction in stainless steel jars without catalyst addition

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Abstract

The mechanochemical and selective reduction of aryl nitro and aryl/alkyl azide derivatives, with either formate salts or hydrazine, to the corresponding, synthetically useful amines occurs in excellent yields in a planetary ball mill without the addition of a catalyst. This newly developed and solvent-free protocol is efficient, fast and does not require the addition of a metal hydrogenation catalyst as the stainless steel jar itself fulfils that role. The method has been applied to a broad range of compounds and excellent yields have been obtained. The formylation of alkyl amines has been successfully performed, by means of mechanochemical activation, in the presence of ammonium formate alone.

Graphical abstract: Highly efficient nitrobenzene and alkyl/aryl azide reduction in stainless steel jars without catalyst addition

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Publication details

The article was received on 19 Aug 2018, accepted on 16 Oct 2018 and first published on 17 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ04240C
Citation: New J. Chem., 2018,42, 18881-18888
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    Highly efficient nitrobenzene and alkyl/aryl azide reduction in stainless steel jars without catalyst addition

    K. Martina, F. Baricco, S. Tagliapietra, M. J. Moran, G. Cravotto and P. Cintas, New J. Chem., 2018, 42, 18881
    DOI: 10.1039/C8NJ04240C

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