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Design and application of a fluorogenic receptor for selective sensing of cations, small neutral molecules, and anions

Abstract

Based on the strategic design, we report here an unprecedented single-molecular multianalyte fluorogenic receptor behaviour of the sodium salt of N-(methyl-2-thiophenyl)-L-tyrosine (NaHTyrthio), wherein it shows selective sensing of a cation (Cu2+), small neutral molecules (nitrobenzene and aniline) and an anion (F-) at the ppm or ppb level in aqueous methanol. The judicious interweaving of two fluorophores (phenol and thiophene) in NaHTyrthio is based on the fact that emission wavelengths for the two fluorophores (phenol: 320 nm; thiophene: ̴440 nm) are well separated upon excitation at two different wavelengths (270 nm and 395 nm, respectively). The fluorescence quenching serves as a signal for sensing of Cu2+ and nitrobenzene (attributed to the phenol part) along with F- (attributed to the thiophene part) while sensing of aniline is ascribed by the shift in emission wavelength of the phenol part of the receptor. To the best of our knowledge, this is the first time a single receptor has been developed to detect selectively a cation (Cu2+), neutral small molecules (nitrobenzene and aniline) and an anion (F-) using a single analytical technique. In each case, the nature and level of the receptor-analyte interactions are established through fluorescence lifetime measurements, NMR titrimetry experiments, and quenching constants calculated from the Stern-Volmer plots.

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Publication details

The article was received on 07 Aug 2018, accepted on 21 Sep 2018 and first published on 21 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ03998D
Citation: New J. Chem., 2018, Accepted Manuscript
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    Design and application of a fluorogenic receptor for selective sensing of cations, small neutral molecules, and anions

    N. Kumar and S. Mandal, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03998D

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