Jump to main content
Jump to site search

Mussel-inspired preparation of C60 nanoparticles as photo-driven DNA cleavage reagents


Construction and designing favorable water-dispersible fullerenes and their derivatives is of huge importance for biological applications addressing DNA-cleavage and photodynamic therapy (PDT). In the present work, a mild, green and facile synthetic approach for the preparation of C60 nanoparticles was developed for the first time via the combination of mussel-inspired chemistry and the Michael addition reaction. The resultant C60-PDA-PEI nanoparticles were characterized by transmission electron microscopy (TEM), dynamic laser scattering (DLS), Fourier-transform infrared spectroscopy (FT-IR), Raman spectra, X-ray photoelectron spectra (XPS) and Thermogravimetric analysis (TGA), demonstrating that the above two-step strategy allows easy access to the preparation of the well water-dispersible fullerene derivatives. Benefiting from the unique nanostructure, the versatile C60-PDA-PEI nanoparticles display a uniform hydrodynamic size of 160 nm in water, and efficient 1O2 generation under irradiation. Furthermore, the good ability of cleaving DNA under visible light at a mass concentration of 62.5 ng/μL, making them highly potential for PDT agents. This universal approach described in this work is capable of introducing many other functional molecules onto PDA-modified fullerenes, thus extending the possible applications of fullerene-based species in many fields of biological technology and pharmaceutical chemistry.

Back to tab navigation

Supplementary files

Publication details

The article was accepted on 30 Sep 2018 and first published on 02 Oct 2018

Article type: Paper
DOI: 10.1039/C8NJ03970D
Citation: New J. Chem., 2018, Accepted Manuscript
  •   Request permissions

    Mussel-inspired preparation of C60 nanoparticles as photo-driven DNA cleavage reagents

    Y. Ma, X. Zhang, Y. Cheng, X. Chen, Y. Li and A. Zhang, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03970D

Search articles by author