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Issue 22, 2018
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Mussel-inspired preparation of C60 nanoparticles as photo-driven DNA cleavage reagents

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Abstract

Designing and constructing favorable water-dispersible fullerenes and their derivatives are of huge importance for biological applications addressing DNA-cleavage and photodynamic therapy (PDT). In the present work, a mild, green and facile synthetic approach for the preparation of C60 nanoparticles was developed for the first time via the combination of mussel-inspired chemistry and the Michael addition reaction. The resultant C60–PDA–PEI nanoparticles were characterized by transmission electron microscopy (TEM), dynamic laser scattering (DLS), Fourier-transform infrared spectroscopy (FT-IR), Raman spectra, X-ray photoelectron spectra (XPS) and thermogravimetric analysis (TGA), demonstrating that the above two-step strategy allows easy access to the preparation of highly water-dispersible fullerene derivatives. Benefiting from their unique nanostructure, the versatile C60–PDA–PEI nanoparticles display a uniform hydrodynamic size of 160 nm in water and efficient 1O2 generation under irradiation. Furthermore, the good ability of cleaving DNA under visible light at a mass concentration of 62.5 ng μL−1 gives them high potential as PDT agents. The universal approach described in this work is capable of introducing many other functional molecules onto PDA-modified fullerenes, thus extending the possible applications of fullerene-based species in many fields of biotechnology and pharmaceutical chemistry.

Graphical abstract: Mussel-inspired preparation of C60 nanoparticles as photo-driven DNA cleavage reagents

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Publication details

The article was received on 06 Aug 2018, accepted on 30 Sep 2018 and first published on 02 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ03970D
Citation: New J. Chem., 2018,42, 18102-18108
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    Mussel-inspired preparation of C60 nanoparticles as photo-driven DNA cleavage reagents

    Y. Ma, X. Zhang, Y. Cheng, X. Chen, Y. Li and A. Zhang, New J. Chem., 2018, 42, 18102
    DOI: 10.1039/C8NJ03970D

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