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Issue 23, 2018
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PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives

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Abstract

This paper describes a mild phenyliodine diacetate mediated method for selective chlorination, bromination, and iodination of indole C–H bonds using sodium halide as a source for analogous halogenations. The combination of NaX and phenyliodine diacetate provides an invincible system for halogenation of indoles. This protocol was compatible with a wide array of indole substrates and provides straight forward access to potential halogenated arenes.

Graphical abstract: PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives

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Publication details

The article was received on 31 Jul 2018, accepted on 17 Oct 2018 and first published on 18 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ03822H
Citation: New J. Chem., 2018,42, 18889-18893
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    PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives

    V. Himabindu, S. P. Parvathaneni and V. J. Rao, New J. Chem., 2018, 42, 18889
    DOI: 10.1039/C8NJ03822H

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