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The synthesis of core-shell Cu9S5@mSiO2-ICG@PEG-LA for photothermal and photodynamic therapy

Abstract

Recently, with strong NIR absorption, CuSx nanomaterials have been considered as potential photothermal and photodynamic agents on anticancer. Here, Cu9S5 nanoparticles were synthesized as core and coated with mesoporous silica to construct the core-shell nanostructure (Cu9S5@mSiO2). The as-synthesized Cu9S5@mSiO2 nanomaterial possesses uniform sphere morphology about 50 nm in size. Considering the plenty porous structure, Cu9S5@mSiO2-NH2 was used as nanocarrier to possess high loading efficiency of photosensitizer indocyanine green (ICG). Under 808 nm NIR light illumination, the temperature can climb to 55.8 ◦C (3 w/cm2) and the high photo-thermal convertor is ascribed the combined action of Cu9S5 and ICG. Moreover, Cu9S5@mSiO2-ICG also reveal the illumination-dependent ROS generation. In addition, polyethylene glycol (PEG) and lactose acid (PEG-LA) was prepared and grafted outside Cu9S5@mSiO2-ICG to further guarantee the targeting and cell uptake performance. Under the synergistic effect of PTT and PDT, Cu9S5@mSiO2-ICG@PEG-LA nanocomposite show enhanced cytotoxicity to human hepatoma cells (HepG2), making a promising candidate of nanomedicine on antitumor.

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Publication details

The article was received on 25 Jul 2018, accepted on 01 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ03712D
Citation: New J. Chem., 2018, Accepted Manuscript
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    The synthesis of core-shell Cu9S5@mSiO2-ICG@PEG-LA for photothermal and photodynamic therapy

    N. An, Y. Wang, M. Li, H. Lin and F. Qu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03712D

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