Jump to main content
Jump to site search

Issue 24, 2018
Previous Article Next Article

An efficient cyclization of lapachol to new benzo[h]chromene hybrid compounds: a stepwise vs. one-pot esterification-click (CuAAC) study

Author affiliations

Abstract

A straightforward one-pot vs. stepwise esterification of lapachol was performed to obtain highly diversified heterocycles. Whereas the one-pot esterification leads to mono esterified lapachol, the stepwise approach generated benzo[h]chromene. Furthermore, benzo[h]chromene architectures with embedded triazole moieties were synthesized through late-stage functionalization of the benzo[h]chromene terminal alkyne moiety by copper catalyzed 1,3-dipolar cycloaddition (CuAAC) in a one-pot procedure.

Graphical abstract: An efficient cyclization of lapachol to new benzo[h]chromene hybrid compounds: a stepwise vs. one-pot esterification-click (CuAAC) study

Back to tab navigation

Supplementary files

Article information


Submitted
24 Jul 2018
Accepted
05 Nov 2018
First published
12 Nov 2018

New J. Chem., 2018,42, 19591-19599
Article type
Paper

An efficient cyclization of lapachol to new benzo[h]chromene hybrid compounds: a stepwise vs. one-pot esterification-click (CuAAC) study

A. F. de la Torre, A. Ali, B. Westermann, G. Schmeda-Hirschmann and M. Walter Pertino, New J. Chem., 2018, 42, 19591
DOI: 10.1039/C8NJ03699C

Social activity

Search articles by author

Spotlight

Advertisements