Jump to main content
Jump to site search


Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems

Author affiliations

Abstract

Curcumin has shown therapeutic activity against triple-negative breast cancer (TNBC) cells, but it shows low efficacy and low bioavailability when administered as a free drug. We have developed a general synthesis strategy to encapsulate the natural molecule curcumin in monodispersed isoreticular nanoscale metal organic framework (NMOF-3) nanoparticles for targeted drug delivery in triple-negative breast cancer cells (TNBC). The cytotoxicity of IRMOF-3, curcumin-loaded IRMOF-3 (IRMOF-3@CCM) and folic acid-conjugated curcumin-loaded IRMOF-3 (IRMOF-3@CCM@FA) in human and mice TNBC were tested. IRMOF3@CCM@FA induces apoptosis by upregulating of Bax and downregulating of Bcl-2, and it further upregulates JNK and p53 in human TNBC cells. Simultaneously, we studied their effects in mice bearing TNBC induced by 4T1 cells. In in vivo studies, mice receiving targeted delivery of curcumin had increased survivability and reduced tumor volume compared with those observed for mice receiving non-targeted delivery. Our results highlight that folate-conjugated curcumin-loaded IRMOF-3 may be a useful therapeutic agent to treat TNBC.

Graphical abstract: Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jul 2018, accepted on 02 Nov 2018 and first published on 08 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ03350A
Citation: New J. Chem., 2018, Advance Article
  •   Request permissions

    Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems

    D. Laha, K. Pal, A. R. Chowdhuri, P. K. Parida, S. K. Sahu, K. Jana and P. Karmakar, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ03350A

Search articles by author

Spotlight

Advertisements