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A naphthalimide based fast and selective fluorescent probe for hypochlorous acid/ hypochlorite and its application for bioimaging

Abstract

A reversible and mitochondria targetable fluorescent probe (Nap-Se) bearing 1, 8-naphthalimide and a selenomorpholine fragment was designed and synthesized. The probe showed highly selective, sensitive and fast response (< 2s) to hypochlorous acid/ hypochlorite in phosphate buffer saline solution. Cell imaging studies confirmed that probe Nap-Se was specifically localized in mitochondria of living cells and could be used to monitor the levels of endogenous and exogenous HClO/ClO in RAW264.7 cells.

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Publication details

The article was received on 28 Jun 2018, accepted on 06 Aug 2018 and first published on 07 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ03208D
Citation: New J. Chem., 2018, Accepted Manuscript
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    A naphthalimide based fast and selective fluorescent probe for hypochlorous acid/ hypochlorite and its application for bioimaging

    X. Lv, X. Yuan, Y. Wang and W. Guo, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03208D

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