Jump to main content
Jump to site search


ISE-potentiometric sensor for the determination of zolmitriptan: Application in plasma, pharmaceutical formulation and in-vitro release profile

Abstract

Six different sensors were fabricated and compared for the potentiometric determination of a widely used serotonin receptor agonist; Zolmitriptan (ZT), that is mainly used for the treatment of acute migraine attacks. Owing to its five-membered lactone ring, ZT was found susceptible to alkaline hydrolysis. The composition of the PVC-membrane was systematically optimized via comparing the response of different membranes. Membranes (1 to 4) contained dioctyl sebacate (DOS) in addition to different ion exchangers; namely, sodium tetraphenylborate (sensor 1), sodium phosphotungstate (sensor 2), sodium phosphomolybdate (sensor 3), and ammonium reineckate (sensor 4). The third sensor demonstrated the best sensitivity and near-Nernstian slope and though was elected for the next step. To assess the plasticizer effect, the relatively non polar plasticizer DOS used in sensor III was compared to a high dielectric constant plasticizer nitrophenyl octyl ether (NPOE) in (sensor 5), the later proved to possess better sensitivity (LOQ = 6.66×10-6), slope (52.821 mV/decade) and response time. The effect of ionophore on the sensor performance was evaluated, where hydroxypropyl β-cyclodextrin was further incorporated as an ionophore (sensor 6), resulting in a remarkably higher sensitivity (LOQ = 3.33×10-6), better near-Nernstian slope (59.915 mV/decade) and faster response time. The pH and temperature effects as well as the selectivity of the ionophore free membrane (sensor 5) and the ionophore containing membrane (sensor 6I) were compared to evaluate the effect of the ionophore on the sensor performance. The developed sensors (5 and 6) were found to be selective for ZT in the presence of different interfering ions as well as ZT alkaline degradation product. The sensors performance were assessed as per IUPAC recommendation and used for the determination of ZT in the presence of its degradation product in the raw material, orodispersable tablets and in spiked plasma samples. The stability of the sensors’ response over a wide pH range (pH 2 to 8) enabled the selectively inline the ZT release profile monitoring in different physiological pH values, in the presence of its hydrolytic degradation product.

Back to tab navigation

Publication details

The article was received on 28 Jun 2018, accepted on 07 Aug 2018 and first published on 07 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ03203C
Citation: New J. Chem., 2018, Accepted Manuscript
  •   Request permissions

    ISE-potentiometric sensor for the determination of zolmitriptan: Application in plasma, pharmaceutical formulation and in-vitro release profile

    A. S. Saad, M. R. Elghobashy, N. S. Mostafa and B. Elzeny, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03203C

Search articles by author

Spotlight

Advertisements