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Coumarin substituted 1,2,4–triazole derived silver(I) and gold(I) complexes: synthesis, characterization and anticancer studies

Abstract

Metal based small molecules are extensively studied for their potential application in cancer treatment. In this regard, a series of sterically–tuned coumarin substituted 1,2,4–triazole–based NHC (N–heterocyclic carbene) precursors (1–12) and their silver(I) complexes of the type [NHC–Ag–NHC]+PF6– (13–18) and [NHC–Ag–OAc] (OAc: acetate) (19–24) and gold(I)–NHC (25–30) complexes have been synthesized and thoroughly characterized. Molecular structure of NHC precursors 7, 9 and 10, silver(I) NHC complexes 13, 14 and 16 and gold(I) NHC complex 26 have been unambiguously established by single crystal X–ray diffraction method. Metal atoms displayed a distorted linear coordination geometry and possess inversion center at metal atom with a series of anagostic–like interactions between the silver atom and different CH modules of NHC ligands. Further, the in vitro anticancer activities of silver(I) (13–18) and gold(I) (25–30) complexes toward two human derived cancer cell lines, the breast cancer (MCF 7) and the colon cancer (HT–29) cell lines, have been examined by SRB assay. All silver(I) complexes evidenced higher anticancer potentials than their gold(I) counterparts toward both the cell lines tested, except complex 18 against MCF 7 cells. Notably, complex 17 exhibited highest anticancer potency than other members of the series with the GI50 value of 0.3540±0.032 and 8.5983±0.98 μM against the MCF 7 and HT–29 cell lines, respectively.

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Publication details

The article was received on 14 Jun 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8NJ02927J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Coumarin substituted 1,2,4–triazole derived silver(I) and gold(I) complexes: synthesis, characterization and anticancer studies

    G. Achar, S. C. R., S. A. Patil, J. Malecki and S. Budagumpi, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02927J

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