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Tungsten doped hydroxyapatite processed at different temperature: dielectric behaviour and anti-microbial aspects

Abstract

Hydroxyapatite is regarded as one of the most significant and emerging biomaterial owing to its biocompatibility with bone/enamel. In this present exertion, tungsten doped hydroxyapatite (W-HAp) nanoparticle has been synthesised via chemical precipitation followed by annealing at different temperatures (800, 1000, 1200oC) and characterized with XRD, FESEM equipped with EDS, TEM, XPS and DTA-TGA. Morphological changes as well as, newly formed phases arise in each sample which also exhibit high mechanical strengths and better young modulus as a result of annealing temperature effects. Maximum dielectric constant/electric polarization is noticed for W-HAp10 composite whereas frequency dependent tangent loss and frequency dependent capacitance is almost similar for the W-HAp8 and W-HAp12 samples. A mechanistic anti-bacterial activity of the W-HAp10 has been explored against gram-negative (E. coli) and gram-positive (S. aureus) bacteria through mortality assay, MIC (Minimum inhibitory concentration), MBC (Minimum bactericidal Concentration), ROS (reactive oxygen species) generation, Fluorescence microscopy, cell wall degradation in FESEM. The bioactivity of W-HAp10 has been monitored in the stimulated body fluid (SBF) attributable to the formation of apatite on its surface. The significant results suggest that the influence of temperature (at 1000oC) along with tungsten doping in hydroxyapatite will be beneficial for the advancement of pathogen-free biomaterial having di-electric activity in medicinal aspects.

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Publication details

The article was received on 06 Jun 2018, accepted on 23 Aug 2018 and first published on 24 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ02801J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Tungsten doped hydroxyapatite processed at different temperature: dielectric behaviour and anti-microbial aspects

    M. Maiti, M. Sarkar, D. Liu, S. Xu, S. Maiti, B. K. Paul and S. Das, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02801J

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