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ELECTROCHEMICAL SYNTHESIS AND IN-VITRO CYTOTOXICITY STUDY OF COPPER(II) CARBOXYLATE WITH DIFFERENT FATTY ACIDS ALKYL CHAIN LENGTH

Abstract

In the present study, an electrochemical technique based on the release of Cu2+ ions from Cu anode in the presence of unsaturated fatty acids with different alkyl chain length has been used to synthesize Cu(II) carboxylates. The fatty acids being used in this study are lauric acid (C12:0) and stearic acid (C18:0). Optimum electrolysis conditions for the synthesis of Cu(II) laurate (CuLa2) and Cu(II) stearate (CuSt2) have been determined to maximize the percentage yield, minimizing energy consumption and loss of Cu anode. This study showed that 99.21% of both compounds were produced with lower energy consumption (~21.01 WhL-1) and anode loss (~0.57 mg L-1) by using the same optimum conditions of 10 V applied voltage for 4 hours of electrolysis time in 0.1 M CH3COONH4 electrolyte solution. The cytotoxicity study on a selected tumor cells (A549 and HeLa) shows that the synthesized compounds give moderate cytotoxic effect with IC50 in the range of 19.50 to 44.67 µM. CuLa2 with C12 alkyl chain provides better cytotoxicity effect on the selected tumor cells based on lower IC50 obtained than CuSt2 with C18 alkyl chain. This shows that the length of the alkyl chain also affects the nature of the compound toxicity on the selected cells.

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Publication details

The article was received on 05 Jun 2018, accepted on 02 Aug 2018 and first published on 06 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ02783H
Citation: New J. Chem., 2018, Accepted Manuscript
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    ELECTROCHEMICAL SYNTHESIS AND IN-VITRO CYTOTOXICITY STUDY OF COPPER(II) CARBOXYLATE WITH DIFFERENT FATTY ACIDS ALKYL CHAIN LENGTH

    N. Nordin, B. H. Yahaya and M. R. Yusop, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02783H

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