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Issue 21, 2018
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NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenes

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Abstract

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.

Graphical abstract: NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenes

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Publication details

The article was received on 03 Jun 2018, accepted on 01 Aug 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ02756K
Citation: New J. Chem., 2018,42, 17732-17739
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    NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenes

    C. Zhang, Y. Shi, L. Zhang, D. Yuan, M. Ban, J. Zheng, D. Liu, S. Guo and D. Cui, New J. Chem., 2018, 42, 17732
    DOI: 10.1039/C8NJ02756K

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