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NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: Synthesis of dihetaryl substituted alkenes

Abstract

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocycle, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.

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Publication details

The article was received on 03 Jun 2018, accepted on 01 Aug 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ02756K
Citation: New J. Chem., 2018, Accepted Manuscript
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    NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: Synthesis of dihetaryl substituted alkenes

    C. Zhang, D. Cui, L. Zhang, Y. Shi, D. Yuan, M. Ban, S. Guo, J. Zheng and D. Liu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02756K

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