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A facile fluorescence assay for rapid and sensitive detection of uric acid based on carbon dots and MnO2 nanosheets

Abstract

Uric acid (UA) is an important biological molecule in human pathologies, which related to many critical diseases. Designing a simple and rapid method for sensitive UA determination is of great significance indeed. Herein we report a novel turn-on fluorescence assay for UA detection based on fluorescence resonance energy transfer (FRET) between carbon dots (C-dots) and MnO2 nanosheets. The MnO2 nanosheets can adsorb C-dots to form nanocomposites with the fluorescence of C-dots quenched via FRET. The fluorescence will be recovered when UA is introduced into the sensing system due to the decomposition of MnO2 nanosheets to Mn2+. Under optimized condition, the fluorescence signal was linearly related to UA concentration in the range of 0.1-200 μM, and the detection limit was as low as 45 nM. Moreover, this developed assay was successfully applied for human urine sample analysis, which indicated that this strategy could be an efficient tool for clinical disease diagnosis.

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Publication details

The article was received on 26 May 2018, accepted on 01 Aug 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ02607F
Citation: New J. Chem., 2018, Accepted Manuscript
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    A facile fluorescence assay for rapid and sensitive detection of uric acid based on carbon dots and MnO2 nanosheets

    J. Yang, Z. Huang, Y. Hu, J. Ge, J. Li and Z. Li, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02607F

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