The Baylis–Hillman reaction: a new continent in organic chemistry – our philosophy, vision and over three decades of research

Abstract

This review describes, in brief, the philosophy, vision and long-term research experience of the senior author (DB) in the area of the Baylis–Hillman (BH) [also known as the Morita–Baylis–Hillman (MBH)] reaction. It presents a clear picture of how the senior author (DB) has (i) uncovered the BH reaction, which was actually buried in the literature, (ii) recognized its high level potential, and (iii) initiated a major research program, nurtured it, elegantly contributed to it, and popularized it from the concealed patent level to the present levels of powerful C–C bond forming reactions, attaining the status of a new continent in organic chemistry. While presenting mostly the contributions of our research group, this brief review also describes some of the important and relevant contributions from other research groups. This article clearly demonstrates the power of molecules containing three proximal functional groups and highlights the unending opportunities, and challenges offered by this fascinating reaction.