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Issue 18, 2018
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Acylhydrazone as a novel “Off–On–Off” fluorescence probe for the sequential detection of Al3+ and F

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Abstract

A new acylhydrazone fluorescence probe, SPBH, was synthesized from salicylaldehyde and 4-(pyridin-4-yl)benzohydrazide (PBH). SPBH exhibited high selectivity and a sensitive fluorescence response towards Al3+, even in the presence of other competing metal ions in DMF/H2O (1 : 1, v/v) medium. And, the chemosensor can even detect Al3+ in the intracellular region of human non-small cell lung cancer H460 cells. The binding phenomenon of SPBH was investigated by 1H NMR spectroscopy and HR-MS. Mass spectrometry analysis showed a 1 : 1 complex formation of SPBH with Al3+. The Job plot also confirmed its 1 : 1 interaction. This SPBH/Al3+ complex exhibited excellent fluorescence “turn-off” properties towards the F anion. Thus, SPBH acts as a sequential fluorescence “Off–On–Off” probe. The limits of detection for Al3+ and F were calculated from the titration curve and found to be 1.1 × 10−7 M and 1.47 × 10−6 M, respectively.

Graphical abstract: Acylhydrazone as a novel “Off–On–Off” fluorescence probe for the sequential detection of Al3+ and F−

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Publication details

The article was received on 18 May 2018, accepted on 27 Jul 2018 and first published on 30 Jul 2018


Article type: Paper
DOI: 10.1039/C8NJ02474J
Citation: New J. Chem., 2018,42, 14978-14985
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    Acylhydrazone as a novel “Off–On–Off” fluorescence probe for the sequential detection of Al3+ and F

    Y. Wu, F. Rahman, M. Z. Bhatti, S. Yu, B. Yang, H. Wang, Z. Li and D. Zhang, New J. Chem., 2018, 42, 14978
    DOI: 10.1039/C8NJ02474J

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