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Imaging of lysosomal pH changes with a novel quinoline/ benzothiazole probe

Abstract

A novel quinoline/benzothiazole pH probe (E)-2-(2-(quinolin-4-yl)vinyl)benzothiazole (BTVQ) was facilely synthesized. BTVQ exhibits remarkable emission response to pH and can image pH changes within the extreme acidity range of 3.0-3.8 with a pKa of 3.52. Moreover, BTVQ displays a notably large Stokes'hift of 110 nm, which can reduce the excitation interference. Application of BTVQ in HeLa cells and E. coli cells are achieved successfully, suggesting that BTVQ can be employed as one of the few lysosome specific probes for imaging acidic intracellular pH changes, especially under extreme-acidity condition in bacteria.

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Publication details

The article was received on 17 May 2018, accepted on 03 Jul 2018 and first published on 04 Jul 2018


Article type: Paper
DOI: 10.1039/C8NJ02455C
Citation: New J. Chem., 2018, Accepted Manuscript
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    Imaging of lysosomal pH changes with a novel quinoline/ benzothiazole probe

    L. Fan, M. Nan, J. Ge, X. Wang, B. Lin, W. Zhang, S. Shuang and C. Dong, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02455C

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