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Issue 19, 2018
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A printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPs–GO/nano-PANI

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Abstract

A novel voltammetric screen printed genosensor has been developed for detecting mutation in a particular sequence of the adenomatous polyposis coli (APC) gene, which is classified as a tumor suppressor gene. This gene prevents uncontrolled growth of cells which can cause cancerous tumors. For this purpose, a screen-printed carbon electrode (SPCE) surface was modified with a nano-polyaniline (nano-PANI) and graphene oxide (GO)-ceria nanocomposite (Ceria NPs–GO/nano-PANI/SPCE). Ceria NPs–GO was a suitable base for label-free immobilizaition of a single strand oligonucleotide probe. The composite was able to catalyze a difference pulse voltammetry (DPV) redox signal of Tris(bipyridine) ruthenium(II) chloride utilized as a redox probe for monitoring the hybridization of DNA. The genosensor displayed excellent performance over the linear range from 1 × 10−5 to 5 × 10−2 μmol L−1 with a limit of detection of 5.7 × 10−6 μmol L−1. Also, it can distinguish a target sequence from three mismatch base sequences successfully.

Graphical abstract: A printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPs–GO/nano-PANI

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Publication details

The article was received on 17 May 2018, accepted on 07 Aug 2018 and first published on 07 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ02437E
Citation: New J. Chem., 2018,42, 15655-15662

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    A printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPs–GO/nano-PANI

    M. Eskandari and F. Faridbod, New J. Chem., 2018, 42, 15655
    DOI: 10.1039/C8NJ02437E

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