Jump to main content
Jump to site search


Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(III) complexes involving azo-appended Schiff base ligands

Author affiliations

Abstract

Herein, we have reported three new Co(III) complexes involving azo-appended Schiff base ligands. All three complexes were characterized using different spectroscopic tools like NMR, FTIR and UV-Vis. The structures of the complexes 1–3, were confirmed by single crystal X-ray diffraction analysis. DFT and TDFFT computations were performed to support the structural and electronic parameters of the complexes. Computed bond distances and angles well resemble those of X-ray data. Absorption and viscometric titration studies revealed that each of these octahedral complexes interacts with CT DNA to result in minor groove binding. The intrinsic binding constants (Kb) were calculated to be 7.90 × 105, 1.35 × 105 and 1.075 × 105 M−1, respectively, for complexes 1–3. Complexes 1–3 also exhibited oxidative DNA cleavage activity in the presence of hydrogen peroxide.

Graphical abstract: Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(iii) complexes involving azo-appended Schiff base ligands

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 May 2018, accepted on 30 Aug 2018 and first published on 30 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ02235F
Citation: New J. Chem., 2018, Advance Article
  •   Request permissions

    Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(III) complexes involving azo-appended Schiff base ligands

    S. Banerjee, R. Patra, P. Ghorai, P. Brandão, S. G. Chowdhury, P. Karmakar and A. Saha, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ02235F

Search articles by author

Spotlight

Advertisements