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Synthesis of New Spiro Pyrrole/Pyrrolizine/Thiazole Derivatives via (3+2) Cycloaddition Reaction

Abstract

A new series of spiro pyrrole/pyrrolizine/thiazole compounds have been synthesized by using (3+2) dipolar cycloaddition via three component condensation reaction of ninhydrin and α-amino acid with different dipolarophiles such as maleimide, malic anhydride, 2-benzyl-2-methylcyclopent-4-ene-1,3-dione and isothiocynates. Another four component protocol has been developed in which reaction of ninhydrin, proline, maleimide and phenacyl bromide to afford the novel library of pyrrolizine derivatives in good yields without use of any catalyst.

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Publication details

The article was received on 01 May 2018, accepted on 03 Jul 2018 and first published on 06 Jul 2018


Article type: Paper
DOI: 10.1039/C8NJ02127A
Citation: New J. Chem., 2018, Accepted Manuscript
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    Synthesis of New Spiro Pyrrole/Pyrrolizine/Thiazole Derivatives via (3+2) Cycloaddition Reaction

    P. R. Likhar, P. R. Mali, N. B. Khomane, B. Sridhar and H. M. Meshram, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02127A

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