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Issue 16, 2018
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Synthesis of new spiro pyrrole/pyrrolizine/thiazole derivatives via (3+2) cycloaddition reactions

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Abstract

A new series of spiro pyrrole/pyrrolizine/thiazole compounds have been synthesized using (3+2) dipolar cycloaddition via three-component condensation reactions of ninhydrin and α-amino acids with different dipolarophiles such as maleimide, malic anhydride, 2-benzyl-2-methylcyclopent-4-ene-1,3-dione and isothiocyanates. Another four-component protocol has been developed in which ninhydrin, proline, maleimide and phenacyl bromides are reacted to afford a novel library of pyrrolizine derivatives in good yields without the use of catalyst.

Graphical abstract: Synthesis of new spiro pyrrole/pyrrolizine/thiazole derivatives via (3+2) cycloaddition reactions

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Publication details

The article was received on 01 May 2018, accepted on 03 Jul 2018 and first published on 06 Jul 2018


Article type: Paper
DOI: 10.1039/C8NJ02127A
Citation: New J. Chem., 2018,42, 13819-13827
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    Synthesis of new spiro pyrrole/pyrrolizine/thiazole derivatives via (3+2) cycloaddition reactions

    P. R. Mali, N. B. Khomane, B. Sridhar, H. M. Meshram and P. R. Likhar, New J. Chem., 2018, 42, 13819
    DOI: 10.1039/C8NJ02127A

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