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A new model of metalloantibiotic: Synthesis, structure and biological activity of a zinc(II) mononuclear complex carrying two enrofloxacin and sulfadiazine antibiotics

Abstract

A new model of Zn-based complex, [Zn(LH)(Erx)(ErxH)]ClO4 (sulfadiazine: LH and enrofloxacin ErxH), has been synthesised with two different but complementary antiobitics (sulfonamide and quinolon) following an easy procedure. To evaluate the synergetic effect of this multicomponent molecule, the mononuclear complexes [Zn(L)2(H2O)(NH3)] and [Zn(Erx)3]- which includes each only one of the two antibiotics (sulfadiazine: LH or enrofloxacin ErxH) were synthesized. All three compound were characterized including crystal structure determination by single-crystal X-ray diffraction. For all the complexes, Enrofloxacin is coordinated to Zn(II) by pyridinone and one oxygen atom of the carboxylate group in a monodente mode.The antibacterial activity determinated by Minimum Inhibitory Concentration on specific bacteria have been studied on free ligands, on the correspondig mononuclear complexes and on our model.

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Publication details

The article was received on 12 Apr 2018, accepted on 06 Aug 2018 and first published on 09 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ01774C
Citation: New J. Chem., 2018, Accepted Manuscript
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    A new model of metalloantibiotic: Synthesis, structure and biological activity of a zinc(II) mononuclear complex carrying two enrofloxacin and sulfadiazine antibiotics

    J. Tommasino, G. Pilet, D. Luneau, A. MESSAI, N. ATTIK, D. DECORET, F. Z. CHERCHALI, A. Boughougal, M. Hologne and C. Sanglar, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01774C

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