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Issue 18, 2018
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Synthesis of poly(L-lactide)/β-cyclodextrin/citrate network modified hydroxyapatite and its biomedical properties

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Abstract

Hydroxyapatite (HA) was modified by the chelation of citric acid and Ca2+ on the surface of HA, followed by cross-linking between the hydroxyl groups of β-cyclodextrin (β-CD) and citrate, and then further in situ ring-opening polymerization of L-lactide over the hydroxyl groups. The modification of HA adjusted its surface properties and reduced the particle size. The synthesized PLA-CD-HA-72 exhibited the good adhesion of mesenchymal stem cells (MSCs) of Wistar rats, higher viability of MSCs and larger osteoinductivity. The results indicated that the PLA-CD-HA-72 possessed a rather large biocompatibility and bioactivity, and it could be a promising candidate as a bone tissue engineering material.

Graphical abstract: Synthesis of poly(l-lactide)/β-cyclodextrin/citrate network modified hydroxyapatite and its biomedical properties

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Publication details

The article was received on 11 Mar 2018, accepted on 23 Jun 2018 and first published on 25 Jun 2018


Article type: Letter
DOI: 10.1039/C8NJ01194J
Citation: New J. Chem., 2018,42, 14729-14732
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    Synthesis of poly(L-lactide)/β-cyclodextrin/citrate network modified hydroxyapatite and its biomedical properties

    W. Yi, L. Li, H. He, Z. Hao, B. Liu, Z. Chao and Y. Shen, New J. Chem., 2018, 42, 14729
    DOI: 10.1039/C8NJ01194J

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