Synthesis of poly(l-lactide)/β-cyclodextrin/citrate network modified hydroxyapatite and its biomedical properties

Abstract

Hydroxyapatite (HA) was modified by the chelation of citric acid and Ca²⁺ on the surface of HA, followed by cross-linking between the hydroxyl groups of β-cyclodextrin (β-CD) and citrate, and then further in situ ring-opening polymerization of L-lactide over the hydroxyl groups. The modification of HA adjusted its surface properties and reduced the particle size. The synthesized PLA-CD-HA-72 exhibited the good adhesion of mesenchymal stem cells (MSCs) of Wistar rats, higher viability of MSCs and larger osteoinductivity. The results indicated that the PLA-CD-HA-72 possessed a rather large biocompatibility and bioactivity, and it could be a promising candidate as a bone tissue engineering material.