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Synthesis of Poly(L-lactide)/β-cyclodextrin/citrate Networks Modified Hydroxyapatite and its Biomedical Properties

Abstract

Hydroxyapatite (HA) was modified by chelation of citric acid and Ca on the surface of HA, followed by the cross-linking between the hydroxyl groups of β-cyclodextrin (β-CD) and citrate, and then further in situ ring-opening polymerization of L-lactide over the hydroxyl groups. The modification of HA adjusts the surface properties of it and reduce the particle size. The mesenchymal stem cells (MSCs) of Wistar rat shows better cell adhesion, higher viability and osteoinductivity on the synthesized PLA-CD-HA. The PLA-CD-HA-x is a good candidate for bone tissue engneering material.

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Publication details

The article was received on 11 Mar 2018, accepted on 23 Jun 2018 and first published on 25 Jun 2018


Article type: Letter
DOI: 10.1039/C8NJ01194J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Synthesis of Poly(L-lactide)/β-cyclodextrin/citrate Networks Modified Hydroxyapatite and its Biomedical Properties

    W. Yi, L. Li, H. He, Z. Hao, B. Liu, Y. Shen and Z. Chao, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01194J

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