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Development of a sensor for trivalent iron: AHP fixed on mesoporous silica


Since the emergence of deferiprone as iron(III) chelating drug, hydroxypyridinones have been intensively explored for their high affinity for trivalent metal ions and ability to form complexes at physiological pH with a low toxicity. For instance, they were employed as carriers of La(III), in therapy for bone diseases or to remove Gd(III) from Gd-based contrast agents. We believe that a pyridinone-based sensor could be useful for iron(III) monitoring, so herein a novel chelating solid-phase, resulting from the functionalization of a mesoporous silica MCM-41, with the hydroxypyridinone, N(3’-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone (AHP), as active site, is presented. The physico-chemical characterization of the new solid device, named AHP-MCM41@, demonstrated that AHP moiety was covalently anchored on silica surface; the active sites concentration was found around 0.4 mmol/g. The sorption of Fe(III) from aqueous solution is rather rapid. About the behaviour of soluble AHP, it forms with iron(III) a very rich variety of complexes, typical of all the analogue O,O donor ligands, dominated by 1:3=M:L complexes. Could complexes with so high stoichiometry be retained in the solid phase? The answer is yes: the existence of these different species in the solid was suggested from sorption isotherm results and from sorption experiments as a function of the solution pH, also in the presence of a competitive ligand. Furthermore, the complexes in the solid phase were demonstrated via solid vis-spectrophotometry: these species showed identical colour variations of those formed in solution. Such complexes in solid phase have never been reported in the literature. The intense colour of the solid phase in presence of iron(III) is promising also for a naked eye detection.

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Publication details

The article was received on 20 Feb 2018, accepted on 25 Jul 2018 and first published on 26 Jul 2018

Article type: Paper
DOI: 10.1039/C8NJ00869H
Citation: New J. Chem., 2018, Accepted Manuscript
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    Development of a sensor for trivalent iron: AHP fixed on mesoporous silica

    R. Biesuz, A. Santos, V. M. Nurchi and G. Alberti, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00869H

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