Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Syntheses, structures and anti-tumor activity of four organotin(IV) dicarboxylates based on (1,3,4-thiadiazole-2,5-diyldithio)diacetic acid

Author affiliations


Four novel organotin complexes, [(Me3Sn)2(O2CCH2S)2C2N2S]n (1), [(Me2Sn)2(O2CCH2S)2C2N2S(μ3-O)]n (2), [(n-Bu3Sn)2(O2CCH2S)2C2N2S]n (3) and [(n-Bu2Sn)(O2CCH2S)2C2N2S]n (4), derived from flexible (1,3,4-thiadiazole-2,5-diyldithio)diacetic acid (H2tzda), have been synthesized and characterized by elemental analysis, FT-IR, NMR and X-ray crystallography. The structural analysis reveals that complexes 1 and 2 display a 1D pipeline-like and 1D ladder chain structure, respectively. Complex 1 contains interconnected 26-membered macrocycles, while complex 2 is made up of the typical ladder tetraorganodistannoxane unit containing 26-membered macrocycles. In addition, the molecules of complexes 1 and 2 are further linked through intermolecular C–H⋯O interactions into a 3D and 2D infinite supramolecular structure, respectively. Complex 3 shows a 2D corrugated polymeric structure constructed by 34-membered macrocycles. Complex 4 adopts a 1D infinite chain structure. Furthermore, in vitro cytotoxicity investigations of complexes 1, 3 and 4 were conducted. Importantly, further cytotoxic assessments of complex 3 against human hepatocellular carcinoma cells (HepG-2) demonstrate that complex 3 could induce an apoptotic retardation effect on proliferation via possible mitochondrial-dependent cross-talk between various signaling proteins and the intracellular p53-Bax-caspases approach should be the major pathway of apoptosis.

Graphical abstract: Syntheses, structures and anti-tumor activity of four organotin(iv) dicarboxylates based on (1,3,4-thiadiazole-2,5-diyldithio)diacetic acid

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jan 2018, accepted on 04 Jun 2018 and first published on 05 Jun 2018

Article type: Paper
DOI: 10.1039/C8NJ00431E
Citation: New J. Chem., 2018,42, 11601-11609
  •   Request permissions

    Syntheses, structures and anti-tumor activity of four organotin(IV) dicarboxylates based on (1,3,4-thiadiazole-2,5-diyldithio)diacetic acid

    F. Yan, C. Ma, Q. Li, S. Zhang, J. Ru, S. Cheng and R. Zhang, New J. Chem., 2018, 42, 11601
    DOI: 10.1039/C8NJ00431E

Search articles by author