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Issue 7, 2018
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Nitroolefin-modified cyclometalated iridium(iii) complexes for tunable detection of biothiols with deep-red emission

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Abstract

Two cyclometalated iridium(III) complexes have been synthesized and utilized as turn-on luminescent probes for the detection of biothiols. These probes exhibited rapid (1 min) luminescence response toward biothiols. It was revealed that emission of probes increased significantly due to the Michael addition between biothiols and the double bond of nitroolefin in the iridium(III) complexes. The process was highly sensitive and the limits of detection for biothiols such as Hcy were evaluated to be 47.6 nM and 232 nM, respectively. The cyclometalated iridium(III) complex bearing electron-withdrawing ester groups showed deep-red emission at 643 nm in the presence of biothiols. It was further successfully applied in cell imaging.

Graphical abstract: Nitroolefin-modified cyclometalated iridium(iii) complexes for tunable detection of biothiols with deep-red emission

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Supplementary files

Article information


Submitted
18 Jan 2018
Accepted
23 Feb 2018
First published
28 Feb 2018

New J. Chem., 2018,42, 5508-5513
Article type
Paper

Nitroolefin-modified cyclometalated iridium(III) complexes for tunable detection of biothiols with deep-red emission

M. Zhao, Y. Pan, X. Wang, X. Gao and D. Chao, New J. Chem., 2018, 42, 5508
DOI: 10.1039/C8NJ00314A

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