Jump to main content
Jump to site search

Issue 5, 2018
Previous Article Next Article

A highly selective and sensitive chemosensor for L-tryptophan by employing a Schiff based Cu(II) complex

Author affiliations


A new Cu(II) complex C40H38N4CuO2 (1) was synthesized and characterized by elemental analysis, mass spectrometry and also authenticated by single crystal X-ray studies. Structural analysis of 1 reveals the distorted square planar geometry around the Cu(II) centre and the presence of C–H⋯O and N–H⋯π hydrogen bonding interactions. The sensing behaviour of 1 towards L-tryptophan (L-Trp) was identified by UV-vis spectroscopic and cyclic voltammetry experiments. In the UV titration of 1 with L-Trp, four distinct isosbestic points were observed. Furthermore, on modifying the surface of the glassy carbon electrode (GCE) by 1 (1-GCE) the oxidation potential of L-Trp at +0.32 V is revealed, which is considerably lower than the values previously reported for other electrodes. Additionally, the 1-GCE can detect L-Trp with a noteworthy detection limit (185 nM), sensitivity (3.156 μA μM−1 cm−2) and with distinguished selectivity in the presence of various other amino acids. The 1-GCE also displays excellent reproducibility, repeatability and long term stability. Finally, electrochemical impedance spectroscopy (EIS) investigations were carried out to gauge the effects of modification with 1 on the characteristics of the GCE. Moreover, the molecular docking study of 1 with various proteins reveals the π–π stacking interaction with L-Trp.

Graphical abstract: A highly selective and sensitive chemosensor for l-tryptophan by employing a Schiff based Cu(ii) complex

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Nov 2017, accepted on 17 Jan 2018 and first published on 18 Jan 2018

Article type: Paper
DOI: 10.1039/C7NJ04595F
Citation: New J. Chem., 2018,42, 3509-3518
  •   Request permissions

    A highly selective and sensitive chemosensor for L-tryptophan by employing a Schiff based Cu(II) complex

    A. K. Saini, M. Saraf, P. Kumari and S. M. Mobin, New J. Chem., 2018, 42, 3509
    DOI: 10.1039/C7NJ04595F

Search articles by author