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Issue 3, 2018
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γ-Fe2O3@Cu3Al-LDH-N-amidinoglycine: a new amphoteric and reusable magnetic nanocatalyst for the synthesis of new pyrimidonaphthyridine derivatives and their antioxidant and antifungal activity evaluation

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Abstract

The synthesis of a novel layered double hydroxide (LDH)-based N-amidinoglycine-functionalized magnetic nanocomposite, γ-Fe2O3@Cu3Al-LDH-N-amidinoglycine, has been described. The structure of the synthesized nanoparticles was characterized by different physicochemical techniques such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM), and using a vibrating sample magnetometer (VSM). These newly developed magnetic nanoparticles have been explored as a magnetically separable amphoteric nanocatalyst for the synthesis of new pyrimido[4,5-b][1,8]naphthyridine-7-carbonitrile derivatives in excellent yields via one-pot three-component reaction between aldehydes, 3-cyano-6-hydroxy-4-methyl-pyridin-2(1H)-one, and N,N-dimethyl-6-aminouracil. In the subsequent part of the present research, these synthesized pyrimido[4,5-b][1,8]naphthyridines were evaluated for their antioxidant and antifungal activities in vitro by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and PDA (potato dextrose agar) medium, respectively.

Graphical abstract: γ-Fe2O3@Cu3Al-LDH-N-amidinoglycine: a new amphoteric and reusable magnetic nanocatalyst for the synthesis of new pyrimidonaphthyridine derivatives and their antioxidant and antifungal activity evaluation

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Supplementary files

Article information


Submitted
05 Oct 2017
Accepted
19 Dec 2017
First published
09 Jan 2018

New J. Chem., 2018,42, 1796-1805
Article type
Paper

γ-Fe2O3@Cu3Al-LDH-N-amidinoglycine: a new amphoteric and reusable magnetic nanocatalyst for the synthesis of new pyrimidonaphthyridine derivatives and their antioxidant and antifungal activity evaluation

D. Azarifar, M. Ghaemi, R. Karamian, Y. abbasi, F. Ghasemlou and M. Asadbegy, New J. Chem., 2018, 42, 1796 DOI: 10.1039/C7NJ03803H

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