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DePEGylation strategies to increase cancer nanomedicine efficacy

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Abstract

To maximize drug targeting to solid tumors, cancer nanomedicines with prolonged circulation times are required. To this end, poly(ethylene glycol) (PEG) has been widely used as a steric shield of nanomedicine surfaces to minimize serum protein absorption (opsonisation) and subsequent recognition and clearance by cells of the mononuclear phagocyte system (MPS). However, PEG also inhibits interactions of nanomedicines with target cancer cells, limiting the effective drug dose that can be reached within the target tumor. To overcome this dilemma, nanomedicines with stimuli-responsive cleavable PEG functionality have been developed. These benefit from both long circulation lifetimes en route to the targeted tumor as well as efficient drug delivery to target cancer cells. In this review, various stimuli-responsive strategies to dePEGylate nanomedicines within the tumor microenvironment will be critically reviewed.

Graphical abstract: DePEGylation strategies to increase cancer nanomedicine efficacy

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Publication details

The article was received on 14 Nov 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Minireview
DOI: 10.1039/C8NH00417J
Citation: Nanoscale Horiz., 2019, Advance Article
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    DePEGylation strategies to increase cancer nanomedicine efficacy

    L. Kong, F. Campbell and A. Kros, Nanoscale Horiz., 2019, Advance Article , DOI: 10.1039/C8NH00417J

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